Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Parkinson's disease (PD) is a neurodegenerative disease characterized by deposition of α-
synuclein and aggregation of Lewy bodies. Cholesterol is involved with PD neuropathology …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …

Beta-glucocerebrosidase is a lysosomal hydrolase, encoded by GBA1 that represents the
most common risk gene associated with Parkinson's disease (PD) and Lewy Body …

The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …

Many diseases of the central nervous system are age-associated and do not directly result
from genetic mutations. These include late-onset neurodegenerative diseases (NDDs) …

Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset
neurodegenerative disease mainly affecting motor neurons. By screening chemical …

Summary The microRNA (miRNA) miR-124 has been employed supplementary to
neurogenic transcription factors (TFs) and other miRNAs to enhance direct neurogenic …

Parkinson's disease is typically characterized by the progressive loss of dopaminergic
neurons in the substantia nigra pars compacta. Many studies have been performed based …

Proximity to telomeres (i) and high adenine and thymine (A+ T) content (ii) are two factors
associated with high mutation rates in human chromosomes. We have previously shown …