Commensal fungi in intestinal health and disease
The microbiota is known to influence several facets of mammalian development, digestion
and disease. Most studies of the microbiota have focused on the bacterial component, but …
and disease. Most studies of the microbiota have focused on the bacterial component, but …
[HTML][HTML] Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models
Ulcerative colitis (UC) is an inflammatory bowel disease with increasing incidence in the
world, especially in developing countries. Although knowledge of its pathogenesis has …
world, especially in developing countries. Although knowledge of its pathogenesis has …
Cell-programmed nutrient partitioning in the tumour microenvironment
Cancer cells characteristically consume glucose through Warburg metabolism, a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour …
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour …
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression
Q Zhang, X Yang, J Wu, S Ye, J Gong, WM Cheng… - Cell discovery, 2023 - nature.com
Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …
Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues
Gastrointestinal cancers (GICs) and neuroendocrine tumors (NETs) are often refractory to
therapy after metastasis. Adoptive cell therapy using chimeric antigen receptor (CAR) T …
therapy after metastasis. Adoptive cell therapy using chimeric antigen receptor (CAR) T …
Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer
Previously, a synbiotic combination of probiotic Lactobacillus gasseri 505 (LG) and a new
prebiotic, Cudrania tricuspidata leaf extract (CT) in fermented milk, designated FCT, showed …
prebiotic, Cudrania tricuspidata leaf extract (CT) in fermented milk, designated FCT, showed …
The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling
B Chen, MP Dragomir, L Fabris, R Bayraktar… - Gastroenterology, 2020 - Elsevier
Background & Aims Chromosomal instability (CIN) is a carcinogenesis event that promotes
metastasis and resistance to therapy by unclear mechanisms. Expression of the colon …
metastasis and resistance to therapy by unclear mechanisms. Expression of the colon …
Nobiletin and derivatives: functional compounds from citrus fruit peel for colon cancer chemoprevention
The search for effective methods of cancer treatment and prevention has been a continuous
effort since the disease was discovered. Recently, there has been increasing interest in …
effort since the disease was discovered. Recently, there has been increasing interest in …
Mouse tumor models for advanced cancer immunotherapy
Recent advances in the development of new methods of cancer immunotherapy require the
production of complex cancer animal models that reliably reflect the complexity of the tumor …
production of complex cancer animal models that reliably reflect the complexity of the tumor …
Emodin inhibits inflammation, carcinogenesis, and cancer progression in the AOM/DSS model of colitis-associated intestinal tumorigenesis
Y Zhang, W Pu, M Bousquenaud, S Cattin… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic
inflammation contributes to CRC development and progression. Emodin, is a natural …
inflammation contributes to CRC development and progression. Emodin, is a natural …