The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches
D Cruceriu, O Baldasici, O Balacescu… - Cellular Oncology, 2020 - Springer
Background Breast cancer is the most prevalent cancer among women worldwide and the
fifth cause of death among all cancer patients. Breast cancer development is driven by …
fifth cause of death among all cancer patients. Breast cancer development is driven by …
The AP-1 transcriptional complex: Local switch or remote command?
F Bejjani, E Evanno, K Zibara, M Piechaczyk… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
Static and dynamic DNA loops form AP-1-bound activation hubs during macrophage development
The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …
structural and regulatory chromatin loops important for coordinating changes in transcription …
Tumor necrosis factor α blockade: an opportunity to tackle breast cancer
MF Mercogliano, S Bruni, PV Elizalde… - Frontiers in …, 2020 - frontiersin.org
Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …
by malignancy in women and represents a main problem for public health worldwide. Tumor …
[HTML][HTML] LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma
Long non-coding RNA (lncRNAs) play a critical role in the development of cancers. LncRNA
metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has recently been …
metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has recently been …
[HTML][HTML] Batf pioneers the reorganization of chromatin in developing effector T cells via Ets1-dependent recruitment of Ctcf
The basic leucine zipper transcription factor activating transcription factor-like (Batf)
contributes to transcriptional programming of multiple effector T cells and is required for T …
contributes to transcriptional programming of multiple effector T cells and is required for T …
Tumor‐associated macrophages promote prostate cancer progression via exosome‐mediated miR‐95 transfer
H Guan, R Peng, F Fang, L Mao, Z Chen… - Journal of Cellular …, 2020 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are vital constituents in mediating cell‐to‐cell
communication within the tumor microenvironment. However, the molecular mechanisms …
communication within the tumor microenvironment. However, the molecular mechanisms …
[HTML][HTML] Oncogenic notch promotes long-range regulatory interactions within hyperconnected 3D cliques
Chromatin loops enable transcription-factor-bound distal enhancers to interact with their
target promoters to regulate transcriptional programs. Although developmental transcription …
target promoters to regulate transcriptional programs. Although developmental transcription …
AP-1 is a key regulator of proinflammatory cytokine TNFα-mediated triple-negative breast cancer progression
Triple-negative breast cancer (TNBC) represents a highly aggressive form of breast cancer
with limited treatment options. Proinflammatory cytokines such as TNFα can facilitate tumor …
with limited treatment options. Proinflammatory cytokines such as TNFα can facilitate tumor …
Human microphysiological models of intestinal tissue and gut microbiome
The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption,
digestion, secretion, and elimination of waste products that also hosts immune surveillance …
digestion, secretion, and elimination of waste products that also hosts immune surveillance …