Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic
coding potential. 5′ Splice sites (5′ ss) are the critical elements at the 5′ end of introns …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

We present GraphProt, a computational framework for learning sequence-and structure-
binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental …

Following years of rapid progress identifying the genetic underpinnings of amyotrophic
lateral sclerosis (ALS) and related diseases such as frontotemporal dementia (FTD) …

U1 snRNP plays a critical role in 5ʹ-splice site recognition and is a frequent target of
alternative splicing factors. These factors transiently associate with human U1 snRNP and …

TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under
conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon …

TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are
often associated with the cellular antiviral response. In this report, we provide evidence that …

ABSTRACT W elander distal myopathy (WDM) is an adult onset autosomal dominant
disorder characterized by distal limb weakness, which progresses slowly from the fifth …

Stress granule (SG) formation is a primary mechanism through which gene expression is
rapidly modulated when the eukaryotic cell undergoes cellular stresses (including heat …

All proteins sample a range of conformations at physiologic temperatures and this inherent
flexibility enables them to carry out their prescribed functions. A comprehensive …