Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

J Xie, Y Wang, W Choi, P Jangili, Y Ge, Y Xu… - Chemical Society …, 2021 - pubs.rsc.org
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …

[HTML][HTML] Emerging strategies in enhancing singlet oxygen generation of nano-photosensitizers toward advanced phototherapy

M Tavakkoli Yaraki, B Liu, YN Tan - Nano-Micro Letters, 2022 - Springer
The great promise of photodynamic therapy (PDT) has thrusted the rapid progress of
developing highly effective photosensitizers (PS) in killing cancerous cells and bacteria. To …

GSH-responsive nanoprodrug to inhibit glycolysis and alleviate immunosuppression for cancer therapy

X Liu, Y Li, K Wang, Y Chen, M Shi, X Zhang… - Nano Letters, 2021 - ACS Publications
Blocking energy metabolism of cancer cells and simultaneously stimulating the immune
system to perform immune attack are significant for cancer treatment. However, how to …

Aggregation-induced emission-active micelles: synthesis, characterization, and applications

Y Liu, X Chen, X Liu, W Guan, C Lu - Chemical Society Reviews, 2023 - pubs.rsc.org
Aggregation-induced emission (AIE)-active micelles are a type of fluorescent functional
materials that exhibit enhanced emissions in the aggregated surfactant state. They have …

[HTML][HTML] Antimicrobial photodynamic therapy: Latest developments with a focus on combinatory strategies

R Youf, M Müller, A Balasini, F Thétiot, M Müller… - Pharmaceutics, 2021 - mdpi.com
Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern
therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the …

[HTML][HTML] Stimulus-responsive self-assembled prodrugs in cancer therapy

X Dong, RK Brahma, C Fang, SQ Yao - Chemical Science, 2022 - pubs.rsc.org
Small-molecule prodrugs have become the main toolbox to improve the unfavorable
physicochemical properties of potential therapeutic compounds in contemporary anti-cancer …

Deep downregulation of PD‐L1 by caged peptide‐conjugated AIEgen/miR‐140 nanoparticles for enhanced immunotherapy

J Dai, JJ Hu, X Dong, B Chen, X Dong… - Angewandte Chemie …, 2022 - Wiley Online Library
Downregulating programmed cell death ligand 1 (PD‐L1) protein levels in tumor cells is an
effective way to achieve immune system activation for oncology treatment, but current …

Enhanced chemo-photodynamic therapy of an enzyme-responsive prodrug in bladder cancer patient-derived xenograft models

P Tan, H Cai, Q Wei, X Tang, Q Zhang, M Kopytynski… - Biomaterials, 2021 - Elsevier
Patient-derived xenograft (PDX) models are powerful tools for understanding cancer biology
and drug discovery. In this study, a polymeric nano-sized drug delivery system poly …

Nanoscale covalent organic frameworks with donor–acceptor structure for enhanced photothermal ablation of tumors

R Xia, X Zheng, C Li, X Yuan, J Wang, Z Xie, X Jing - ACS nano, 2021 - ACS Publications
Covalent organic frameworks (COFs) have shown great potential in catalysis and the
biomedical fields, but monodisperse COFs with tunable sizes are hard to obtain. Herein, we …

Nanotherapeutic intervention in photodynamic therapy for cancer

AM Itoo, M Paul, SG Padaga, B Ghosh, S Biswas - ACS omega, 2022 - ACS Publications
The clinical need for photodynamic therapy (PDT) has been growing for several decades.
Notably, PDT is often used in oncology to treat a variety of tumors since it is a low-risk …