Mechanical and biological interactions of implants with the brain and their impact on implant design

D Prodanov, J Delbeke - Frontiers in neuroscience, 2016 - frontiersin.org
Neural prostheses have already a long history and yet the cochlear implant remains the only
success story about a longterm sensory function restoration. On the other hand, neural …

Invasive intraneural interfaces: foreign body reaction issues

F Lotti, F Ranieri, G Vadalà, L Zollo… - Frontiers in …, 2017 - frontiersin.org
Intraneural interfaces are stimulation/registration devices designed to couple the peripheral
nervous system (PNS) with the environment. Over the last years, their use has increased in a …

A survey of fractional-order circuit models for biology and biomedicine

TJ Freeborn - IEEE Journal on emerging and selected topics in …, 2013 - ieeexplore.ieee.org
In this survey, we present many of the fractional-order circuit models used in biomedicine
and biology to fit experimentally collected impedance data. An overview of the different …

Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants

A Prasad, QS Xue, V Sankar, T Nishida… - Journal of neural …, 2012 - iopscience.iop.org
For nearly 55 years, tungsten microwires have been widely used in neurophysiological
experiments in animal models to chronically record neuronal activity. While tungsten …

Implant size and fixation mode strongly influence tissue reactions in the CNS

J Thelin, H Jörntell, E Psouni, M Garwicz… - PloS one, 2011 - journals.plos.org
The function of chronic brain machine interfaces depends on stable electrical contact
between neurons and electrodes. A key step in the development of interfaces is therefore to …

Abiotic-biotic characterization of Pt/Ir microelectrode arrays in chronic implants

A Prasad, QS Xue, R Dieme, V Sankar… - Frontiers in …, 2014 - frontiersin.org
Pt/Ir electrodes have been extensively used in neurophysiology research in recent years as
they provide a more inert recording surface as compared to tungsten or stainless steel …

Quantifying long-term microelectrode array functionality using chronic in vivo impedance testing

A Prasad, JC Sanchez - Journal of neural engineering, 2012 - iopscience.iop.org
Long-term acquisition of high-quality neural recordings is a cornerstone of neuroprosthetic
system design. Mitigating the experimental variability of chronically implanted arrays has …

Long-term changes in the material properties of brain tissue at the implant–tissue interface

A Sridharan, SD Rajan… - Journal of neural …, 2013 - iopscience.iop.org
Objective. Brain tissue undergoes dramatic molecular and cellular remodeling at the implant–
tissue interface that evolves over a period of weeks after implantation. The biomechanical …

The density difference between tissue and neural probes is a key factor for glial scarring

G Lind, CE Linsmeier, J Schouenborg - Scientific reports, 2013 - nature.com
A key to successful chronic neural interfacing is to achieve minimal glial scarring
surrounding the implants, as the astrocytes and microglia may functionally insulate the …

Correlations between histology and neuronal activity recorded by microelectrodes implanted chronically in the cerebral cortex

D McCreery, S Cogan, S Kane… - Journal of neural …, 2016 - iopscience.iop.org
Objective. To quantify relations between the neuronal activity recorded with chronically-
implanted intracortical microelectrodes and the histology of the surrounding tissue, using …