Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

One of the fundamental challenges of physical biology is to understand the relationship
between protein dynamics and function. At physiological temperatures, functional motions …

Magic-angle spinning solid-state NMR spectroscopy is an important technique to study
molecular structure, dynamics and interactions, and is rapidly gaining importance in …

Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding,
aggregation, and cytotoxicity in Huntington's disease. This incurable neurodegenerative …

We introduce a new approach to improve structural and dynamical determination of large
metalloproteins using solid-state nuclear magnetic resonance (NMR) with 1H detection …

We demonstrate sensitive detection of alpha protons of fully protonated proteins by solid‐
state NMR spectroscopy with 100–111 kHz magic‐angle spinning (MAS). The excellent …

When combined with high-frequency (currently∼ 60 kHz) magic-angle spinning (MAS),
proton detection boosts sensitivity and increases coherence lifetimes, resulting in narrow 1 …

Zygomycetous fungal infections pose an emerging medical threat among individuals with
compromised immunity and metabolic abnormalities. Our pathophysiological understanding …

Solid-state nuclear magnetic resonance (ssNMR) spectroscopy enables the structural
characterization of a diverse array of biological assemblies that include amyloid fibrils, non …