Revisiting the rules of life for viruses of microorganisms
Viruses that infect microbial hosts have traditionally been studied in laboratory settings with
a focus on either obligate lysis or persistent lysogeny. In the environment, these infection …
a focus on either obligate lysis or persistent lysogeny. In the environment, these infection …
Single-cell massively-parallel multiplexed microbial sequencing (M3-seq) identifies rare bacterial populations and profiles phage infection
Bacterial populations are highly adaptive. They can respond to stress and survive in shifting
environments. How the behaviours of individual bacteria vary during stress, however, is …
environments. How the behaviours of individual bacteria vary during stress, however, is …
[HTML][HTML] Network resilience
Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …
undesired state when forced across a “tipping point”. Some examples are mass extinctions …
Genetic and life-history traits associated with the distribution of prophages in bacteria
Nearly half of the sequenced bacteria are lysogens and many of their prophages encode
adaptive traits. Yet, the variables driving prophage distribution remain undetermined. We …
adaptive traits. Yet, the variables driving prophage distribution remain undetermined. We …
Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer
Highlights•Phages drive horizontal gene transfer between prokaryotes.•Lysogenic
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …
[HTML][HTML] Cellular decision making and biological noise: from microbes to mammals
Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference …
important and heritable fates without an associated genetic or environmental difference …
Challenges in measuring and understanding biological noise
Biochemical reactions are intrinsically stochastic, leading to variation in the production of
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
Single-cell NF-κB dynamics reveal digital activation and analogue information processing
Cells operate in dynamic environments using extraordinary communication capabilities that
emerge from the interactions of genetic circuitry. The mammalian immune response is a …
emerge from the interactions of genetic circuitry. The mammalian immune response is a …
Origins of regulated cell-to-cell variability
B Snijder, L Pelkmans - Nature reviews Molecular cell biology, 2011 - nature.com
Single-cell measurements and lineage-tracing experiments are revealing that phenotypic
cell-to-cell variability is often the result of deterministic processes, despite the existence of …
cell-to-cell variability is often the result of deterministic processes, despite the existence of …