The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor
readily observed without specialized equipment: it can be seen by, and in, the naked eye …

Retinoblastoma is the prototype genetic cancer: in one or both eyes of young children, most
retinoblastomas are initiated by biallelic mutation of the retinoblastoma tumor suppressor …

Background Despite advancements in globe-preserving treatments, improvements in
retinoblastoma outcomes are inconsistent across income levels and geographical locations …

Background Survivors of heritable retinoblastoma carry a high risk to develop second
cancers. Eye‐preserving radiotherapy raises this risk, while the impact of chemotherapy …

Background Previous studies of hereditary retinoblastoma survivors have reported elevated
mortality, particularly for sarcomas, compared with the general population. However, cause …

Background Patients with heritable retinoblastoma are at risk for bilateral retinoblastoma
and second primary malignancies (SPMs). The incidence of SPM is significantly raised after …

Purpose This study attempted to estimate the impact of eye-preserving therapies for the long-
term prognosis of patients with advanced retinoblastoma with regard to overall survival and …

Background Recent years have seen major changes in the diagnosis and treatment of solid
intraocular tumors, mainly owing to an improved molecular biological understanding of their …

In retinoblastoma research tumor-derived cell lines remain an important model to investigate
tumorigenesis and new therapy options, due to limited tumor material and lack of adequate …

Simple Summary Currently survival from retinoblastoma exceeds 95% in high-
income/resource countries. Life expectancy within the heritable retinoblastoma population is …