Many complex cellular events depend on multiprotein complexes known as molecular
machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to …

Numerous ATPases associated with diverse cellular activities (AAA+) proteins form
hexameric, ring-shaped complexes that function via ATPase-coupled translocation of …

In the cell, proteins are synthesized from N to C terminus and begin to fold during translation.
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …

The ClpAP complex is a conserved bacterial protease that unfolds and degrades proteins
targeted for destruction. The ClpA double-ring hexamer powers substrate unfolding and …

Molecular machines containing double or single AAA+ rings power energy-dependent
protein degradation and other critical cellular processes, including disaggregation and …

Parameter optimization or “data fitting” is a computational process that identifies a set of
parameter values that best describe an experimental data set. Parameter optimization is …

Eukaryotes express three nuclear RNA polymerases (Pols I, II, and III) that are essential for
cell survival. Despite extensive investigation of the three Pols, significant knowledge gaps …

Proteins carry out life's essential functions. Comprehensive proteome analysis technologies
are thus required for a full understanding of the operating principles of biological systems …

Cellular proteostasis involves not only the expression of proteins in response to
environmental needs, but also the timely repair or removal of damaged or unneeded …

Lon is a widely distributed AAA+ (ATPases associated with diverse cellular activities)
protease known for degrading poorly folded and damaged proteins and is often classified as …