Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

Programmed ribosomal frameshifting is a key event during translation of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …

The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …

Impairment of translation can lead to collisions of ribosomes, which constitute an activation
platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic …

Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …

Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …