Fertility control with oral medication

G Pincus, J Rock, CR Garcia, E Rice-Wray… - American journal of …, 1958 - Elsevier
As the outstanding findings resulting from this investigation, we may state the following: 1. 1.
Length of the Menstrual Cycle.—1.1. A. The ingestion of 10 mg. of norethynodrel …

Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation

MH Jeng, CJ Parker, VC Jordan - Cancer Research, 1992 - AACR
Most oral contraceptives (OC) contain a progestin in combination with an estrogen, and the
progestin component in OC includes one of the following 19-nortestosterone derivatives …

Control of Conception by Hormonal Steroids: There is no substantial evidence that the benefits of oral contraceptives are offset by adverse effects.

G Pincus - Science, 1966 - science.org
Experience with the use of progestinestrogen preparations as oral contraceptives indicates
that they inhibit fertility by preventing ovulation and that their action is clearly a physiological …

Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones

F LABRIE, J DROUIN, L FERLAND, L LAGACÉ… - Proceedings of the 1977 …, 1978 - Elsevier
Publisher Summary This chapter discusses the mechanism of action of hypothalamic
hormones in the anterior pituitary gland and specific modulation of their activity by sex …

Effects of certain 19-nor steroids on reproductive processes in animals

G Pincus, MC Chang, ESE Hafez, MX Zarrow, A Merrill - Science, 1956 - science.org
In previous publications we have reported that progesterone and certain of its chemical
relatives are effective inhibitors of ovulation in rabbits, rats, and women (1-4). Among the …

The secretion and metabolism of cortisol and aldosterone in normal and in steroid-treated women

D LAYNE, CJ Meyer, PS Vaishwanar… - The Journal of Clinical …, 1962 - academic.oup.com
The secretion rate and the pattern of metabolism of cortisol and of aldosterone were studied
in women receiving oral doses of Enovid, norethynodrel, ethynylestradiol 3-methyl ether …

Anti-ovulatory and other biological properties of megestrol acetate 17αacetoxy-6 methyl pregna 4: 6-diene-3: 20-dione (BDH 1298)

A David, K Edwards, KP Fellowes… - Reproduction, 1963 - rep.bioscientifica.com
17αAcetoxy-6 methyl pregna 4: 6-diene-3: 20-dione (BDH 1298), has been given the
approved name of Megestrol acetate. It appears to be the most potent anti-ovulatory …

Stereospecificity of the intracellular binding of norethisterone and its A-ring reduced metabolites

BA Chávez, F Vilchis, AE Pérez, GA García… - Journal of steroid …, 1985 - Elsevier
The interaction of norethisterone (NET) and four A-ring reduced metabolites of NET with
cytosol receptors for progesterone (PR), androgen (AR), and estrogen (ER) was …

A comparative study of the metabolic fate of testosterone, 17α-methyl-testosterone, 19-nor-testos-terone, 7α-methyl-19-nor-testosterone and 17α-methyl-estr-5 (10) …

DF Dimick, M Heron, EE Baulieu, MF Jayle - Clinica Chimica Acta, 1961 - Elsevier
Single doses of 150 mg each of five different testosterone and nor-testosterone derivatives
were given to four normal male subjects and urinary excretions of 17-ketosteroids, 17 …

Progestational activity of certain 19-nor steroids and progresterone derivatives

T MIYAKE, G PINCUS - Endocrinology, 1958 - academic.oup.com
Seven 19-norsteroids, 17α-ethinyl-19-nortestosterone (I), 17α-ethinyl-5 (10)-estraenolone
(II), 17α-ethyl-19-nortestosterone (III), 17α-methyl-19-nortestosterone (IV), 17α-propyl-l9 …