On the present and future of dissolution-DNP

JH Ardenkjaer-Larsen - Journal of Magnetic Resonance, 2016 - Elsevier
Dissolution-DNP is a method to create solutions of molecules with nuclear spin polarization
close to unity. The many orders of magnitude signal enhancement have enabled many new …

NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances

AC Pinon, A Capozzi, JH Ardenkjær-Larsen - … Resonance Materials in …, 2021 - Springer
Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of
magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic …

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

A Capozzi, T Cheng, G Boero, C Roussel… - Nature …, 2017 - nature.com
Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic
resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real …

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

AC Pinon, A Capozzi… - Communications Chemistry, 2020 - nature.com
In recent years, hyperpolarization of water protons via dissolution Dynamic Nuclear
Polarization (dDNP) has attracted increasing interest in the magnetic resonance community …

Dissolution DNP for in vivo preclinical studies

A Comment - Journal of Magnetic Resonance, 2016 - Elsevier
The tremendous polarization enhancement afforded by dissolution dynamic nuclear
polarization (DNP) can be taken advantage of to perform preclinical in vivo molecular and …

Efficient Hyperpolarization of U‐13C‐Glucose Using Narrow‐Line UV‐Generated Labile Free Radicals

A Capozzi, S Patel, CP Gunnarsson… - Angewandte Chemie …, 2019 - Wiley Online Library
Free radicals generated by UV‐light irradiation of a frozen solution containing a fraction of
pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) …

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

G Zhang, C Hilty - Magnetic Resonance in Chemistry, 2018 - Wiley Online Library
Sensitivity of detection is one of the most limiting aspects when applying NMR spectroscopy
to current problems in the molecular sciences. A number of hyperpolarization methods exist …

Liquid-State 13C Polarization of 30% through Photoinduced Nonpersistent Radicals

A Capozzi, M Karlsson, JR Petersen… - The Journal of …, 2018 - ACS Publications
Hyperpolarization via dissolution dynamic nuclear polarization (dDNP) is crucial to
significantly increasing the magnetic resonance imaging (MRI) sensitivity, opening up in vivo …

Tailored microstructured hyperpolarizing matrices for optimal magnetic resonance imaging

M Cavaillès, A Bornet, X Jaurand… - Angewandte …, 2018 - Wiley Online Library
Tailoring the physical features and the porous network architecture of silica‐based
hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing …