Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …

Numerous studies found intestinal microbiota alterations which are thought to affect the
development of various diseases through the production of gut-derived metabolites …

Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …

Background & Aims Nonalcoholic fatty liver disease is characterized by excessive hepatic
accumulation of triglycerides. We aimed to identify metabolites that differ in plasma of …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and
other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on …

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function
mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion …

Deficiency of the endoplasmic reticulum (ER) protein seipin results in generalized
lipodystrophy by incompletely understood mechanisms. Here, we report mitochondrial …