New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Abstracts Genomic DNA is modified in a postreplicative manner and several modifications,
the enzymes responsible for their deposition as well as proteins that read these …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Unusual DNA/RNA structures of the C9orf72 repeat may participate in repeat expansions or
pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded …

DNA base modifications diversify the genome and are essential players in development.
Yet, their influence on DNA physical properties and the ensuing effects on genome …

Epigenetic phenomena play a central role in cell regulatory processes and are important
factors for understanding complex human disease. One of the best understood epigenetic …

Cardiovascular disease remains the number one cause of death and disability worldwide
despite significant improvements in diagnosis, prevention, and early intervention efforts …

Highlights•DNA molecules are often bent, twisted, and stretched.•DNA mechanics has been
studied using many theoretical models.•DNA mechanics crucially depends on physiological …

Aims. We describe a liquid chromatography‐tandem mass spectrometry (LC‐MS/MS)
method to quantify and compare simultaneously global methylation and hydroxymethylation …

Evidence is now emerging that early life environment can have lifelong effects on metabolic,
cardiovascular, and pulmonary function in offspring, a concept also known as fetal or …