Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Periodontitis is a term used to describe an inflammatory process, initiated by the plaque
biofilm, that leads to loss of periodontal attachment to the root surface and adjacent alveolar …

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially
superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as …

Not only the 24 or so essential elements, but also nonessential and even radioactive
elements have enormous potential for applications in medicine. In the fight against cancer …

The lungs are directly exposed to higher oxygen concentrations than most other tissues.
Increased oxidative stress is a significant part of the pathogenesis of obstructive lung …

Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Peroxynitrite is formed in biological systems when superoxide and nitric oxide are produced
at near equimolar ratio. Although not a free radical by chemical nature (as it has no unpaired …

A reduced nitric oxide availability is a hallmark of endothelial dysfunction occurring early in
atherosclerosis. Recently, we have shown that plasma nitrite mirrors acute changes in …

Septic shock is a major cause of death following trauma and is a persistent problem in
surgical patients throughout the world. It is characterised by hypotension and vascular …