Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …

Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …

Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …

Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits
called plaques and tangles are neuropathological hallmarks of Alzheimer's disease (AD) …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Oxidative stress is considered as one of the pathogenesis of Alzheimer's disease (AD) and
plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 …

Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Oxidative damage in the brain is one of the earliest drivers of pathology in Alzheimer's
disease (AD) and related dementias, both preceding and exacerbating clinical symptoms. In …

Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …