Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection

A Nisa, FC Kipper, D Panigrahy… - … of Physiology-Cell …, 2022 - journals.physiology.org
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …

DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway

SY Tsai, JA Segovia, TH Chang, IR Morris… - PLoS …, 2014 - journals.plos.org
Pathogen-associated molecular patterns (PAMPs) trigger host immune response by
activating pattern recognition receptors like toll-like receptors (TLRs). However, the …

The role of TLR2 in infectious diseases caused by mycobacteria: from cell biology to therapeutic target

W Hu, HP Spaink - Biology, 2022 - mdpi.com
Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …

Immunometabolism of Phagocytes During Mycobacterium tuberculosis Infection

R Kumar, P Singh, A Kolloli, L Shi, Y Bushkin… - Frontiers in molecular …, 2019 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) remains as a leading killer
among infectious diseases worldwide. The nature of the host immune response dictates …

Viability states of bacteria—specific mechanisms of selected probes

H Sträuber, S Müller - Cytometry Part A, 2010 - Wiley Online Library
Single cell techniques like flow cytometry combined with viability staining can help to obtain
information on viability states of bacteria. Many fluorescent dyes are available for this …

Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection

K Mohareer, S Asalla, S Banerjee - Tuberculosis, 2018 - Elsevier
Tuberculosis (TB) continues to be the leading cause of death by any single infectious agent,
accounting for around 1.7 million annual deaths globally, despite several interventions and …

Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells

X Zhou, T Hong, Q Yu, S Nie, D Gong, T Xiong… - Scientific Reports, 2017 - nature.com
Exopolysaccharides (EPS) from lactic acid bacteria (LAB) have been reported to play vital
parts in the modulation of cell-cycle and apoptosis in cancer cells. However, the …

Receptor‐mediated recognition of mycobacterial pathogens

KE Killick, C Ní Cheallaigh, C O'Farrelly… - Cellular …, 2013 - Wiley Online Library
Mycobacteria are a genus of bacteria that range from the non‐pathogenic M ycobacterium
smegmatis to M ycobacterium tuberculosis, the causative agent of tuberculosis in humans …

Nontuberculous mycobacteria, macrophages, and host innate immune response

M Shamaei, M Mirsaeidi - Infection and immunity, 2021 - Am Soc Microbiol
Although nontuberculous mycobacteria (NTM) are considered opportunistic infections,
incidence and prevalence of NTM infection are increasing worldwide becoming a major …