Natural killer cell therapies
E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment
AL Portillo, JK Monteiro, EA Rojas, TM Ritchie… - Frontiers in …, 2023 - frontiersin.org
The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed
the landscape in the development of novel adoptive cell therapies for treating cancer over …
the landscape in the development of novel adoptive cell therapies for treating cancer over …
Interfering with KIR and NKG2A immune checkpoint axes to unleash NK cell immunotherapy
NA Beelen, VTC Valckx, GMJ Bos, L Wieten - Best Practice & Research …, 2024 - Elsevier
Due to their intrinsic ability to eliminate malignant cells, natural killer (NK) cells emerge as a
promising immunotherapy for cancer. While clinical studies have affirmed the safety of NK …
promising immunotherapy for cancer. While clinical studies have affirmed the safety of NK …
Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?
R Zhao, O Sukocheva, E Tse, M Neganova… - Cell Communication and …, 2024 - Springer
Copper is an important metal micronutrient, required for the balanced growth and normal
physiological functions of human organism. Copper-related toxicity and dysbalanced …
physiological functions of human organism. Copper-related toxicity and dysbalanced …
NK cell-based immunotherapy in hepatocellular carcinoma: An attractive therapeutic option for the next decade
X Wang, T Yang, X Shi - Cellular Signalling, 2024 - Elsevier
Hepatocellular carcinoma (HCC), a major subtype of liver cancer, poses significant
therapeutic challenges due to its late diagnosis and rapid progression. The evolving …
therapeutic challenges due to its late diagnosis and rapid progression. The evolving …
[HTML][HTML] Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer
AM Razmara, LE Farley, RM Harris… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells are cytotoxic cells capable of recognizing
heterogeneous cancer targets without prior sensitization, making them promising prospects …
heterogeneous cancer targets without prior sensitization, making them promising prospects …
[PDF][PDF] Cytokine-Induced Memory-Like NK Cells for Improved Cancer Immunotherapy
Natural Killer (NK) cells are cytotoxic lymphocytes similar to group 1 of the innate lymphoid
cell (ILC1) family since they secrete interferon γ (IFNγ) and tumor necrosis factor (TNF) 1 In …
cell (ILC1) family since they secrete interferon γ (IFNγ) and tumor necrosis factor (TNF) 1 In …
Development of a scalable and robust upstream process for the chemically-defined production of lentiviral vectors for gene-modified cellular immunotherapies
C Ripoll Fiol - 2024 - discovery.ucl.ac.uk
Ex vivo gene-modified cellular immunotherapy, including chimeric antigen receptor (CAR)-T
and CAR-NK cell therapy, is a promising therapeutic modality for the treatment of various …
and CAR-NK cell therapy, is a promising therapeutic modality for the treatment of various …
[HTML][HTML] Approaches to Enhance the Graft-Versus-Tumor Effect of Hematopoietic Cell Transplantation: Addressing an Unmet Need
R Shapiro - dana-farber.org
Allogeneic hematopoietic cell transplantation (HCT) remains a therapeutic mainstay for most
hematologic malignancies, particularly myeloid diseases such as myelodysplastic …
hematologic malignancies, particularly myeloid diseases such as myelodysplastic …