Ocular drug delivery and therapy systems have been extensively investigated with various
methods including direct injections, eye drops and contact lenses. Nowadays, smart contact …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Glaucoma is a common neurodegenerative disease characterized by progressive retinal
ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure …

Optogenetic therapy has emerged as a promising technique for the treatment of ocular
diseases; however, most optogenetic tools rely on external blue light to activate the …

Recent advances in optogenetics hold promise for vision restoration in degenerative eye
diseases. Optogenetics refers to techniques that use light to control the cellular activity of …

Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to
irreversible vision loss. Dysfunction of trabecular meshwork (TM) tissue, a major regulator of …

Activation of autophagy is one of the responses elicited by high intraocular pressure (IOP)
and mechanical stretch in trabecular meshwork (TM) cells. However, the mechanosensor …

During the last few years, the autophagy lysosomal system is emerging as a central cellular
pathway with roles in survival, acting as a housekeeper and stress response mechanism …

Cilia, which either generate coordinated motion or sense environmental cues and transmit
corresponding signals to the cell body, are highly conserved hair-like structures that …

Objectives. Primary cilia are conserved organelles found in polarized mammalian cells that
regulate neuronal growth, migration, and differentiation. Proper cilia formation is essential …