Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

One of the most specific but also challenging properties of the brain is its topographic
organization into distinct modules or cortical areas. In this paper, we first review the concept …

Given the increasing number of neuroimaging publications, the automated knowledge
extraction on brain-behavior associations by quantitative meta-analyses has become a …

Objective: The purpose of this article was to inform the first-line treatment choice between
cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive …

Brain-imaging research has predominantly generated insight by means of classical
statistics, including regression-type analyses and null-hypothesis testing using t-test and …

Depression is a mental disorder characterized by low mood and anhedonia that involves
abnormalities in multiple brain regions and networks. Epidemiological studies demonstrated …

The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …

The structural and functional integrity of subgenual cingulate area 25 (A25) is crucial for
emotional expression and equilibrium. A25 has a key role in affective networks, and its …

Depressed patients exhibit altered levels of immune-inflammatory markers both in the
peripheral blood and in the cerebrospinal fluid (CSF) and inflammatory processes have …

Background As a neuroprogressive illness, depression is accompanied by brain structural
abnormality that extends to many brain regions. However, the progressive structural …