In 1982, Jolad et al. isolated uvaricin, a new antitumor agent, from the roots of Uvaria
acuminata (Annonaceae), a bis-tetrahydrofuranoid fatty acid lactone (1) related to …

The importance of asymmetric synthesis as a tool for obtaining enantiomerically pure
compounds has grown dramatically in the last two decades not only in synthetic organic …

The state-of-the-art in stereoselective synthesis!. Thoroughly revised and updated, this
enlarged second edition offers a plethora of valuable information on methods and reagents …

Vinylidenemetal species, which readily form from terminal alkynes under mild conditions,
have rarely been utilized as reactive intermediates in a catalytic cycle. The conversion of …

This Account deals with an emerging new class of natural products, the linear acetogenins.
These com-pounds are isolated from a worldwide spread family of tropical plants, the …

We have developed highly stereospecific rearrangements of silanol epoxides into 1′-
silanoxy-tetrahydrofurans and 1′-silanoxy-tetrahydropyrans. Upon treatment with Ph3CBF4 …

The oxidation of alkenes to vicinal diols using osmium tetroxide is one of the most selective
and reliable transformations in organic synthesis. The reaction stereospecifically produces a …

Covering: 2005 to 2013Cryptophycins are a family of antimitotic depsipeptides with very
high cytotoxicity even against multi-drug resistant (MDR) cancer cells. The first …

A novel copper-catalyzed intermolecular carboesterification strategy of alkenes with α-
carbonyl alkyl bromides is described. This reaction represents a facile and straightforward …

Stereochemically defined γ-butyrolactones have served as key building blocks in the
syntheses of many types of natural products, including alkaloids, macrocyclic antibiotics …