The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Significance: Central nervous system (CNS) diseases are disorders of the brain and/or
spinal cord and include neurodegenerative diseases such as Alzheimer's disease …

Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In
each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is …

Hypersensitive site 2 located in the beta-globin locus control region confers high levels of
expression to the genes of the beta-globin cluster. A tandem repeat of the consensus …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

Abstract NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular
defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) …

The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription
factors. The basic region of the Maf family is unique among the bZIP factors, and it …

An antioxidant response element (ARE) or an electrophile responsive element (EpRE)
regulate the transcriptional induction of a battery of drug-detoxifying enzymes that are …