Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

Astrocytes contribute to brain inflammation in neurological disorders but the molecular
mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory …

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …

Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …

Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

Short chain fatty acids (SCFAs) being produced during fermentation of non-digestible
polysaccharides are regulatory compounds with the potential to influence inflammatory, as …

A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Stress is a major risk factor in the onset of several neuropsychiatric disorders including
anxiety and depression. Although several studies have shown that social isolation stress …