Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Prion diseases, also known as transmissible spongiform encephalopathies, make up a
group of fatal neurodegenerative disorders linked with the misfolding and aggregation of the …

Conformational transitions of the cellular form of the prion protein, PrP C, into an infectious
isoform, PrP Sc, are considered to be central events in the progression of fatal …

This review presents the main properties of hydroxycinnamic acid (HCA) derivatives and
their potential application as agents for the prevention and treatment of neurodegenerative …

Prion diseases are caused by the propagation of misfolded cellular prion proteins (PrPs). A
completely prion disease-resistant genotype, V127M129, has been identified in Papua New …

Misfolding and aggregation of prion proteins are associated with several neurodegenerative
diseases. Therefore, understanding the mechanism of the misfolding process is of enormous …

The large chronic wasting disease (CWD)-affected cervid population in the USA and
Canada, and the risk of the disease being transmitted to humans through intermediate …

The structural basis of pathways of misfolding of a cellular prion (PrPC) into the toxic scrapie
form (PrPSC) and identification of possible intermediates (eg, PrP*) still eludes us. In this …

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal
neurodegenerative diseases with no approved therapeutics. TSE pathology is characterized …

Here, the interactions between cationic pyridylphenylene dendrimers of the second, third
and fourth generations and full-length ovine prion protein (PrP) were studied using …