B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Signals controlling the generation of regulatory B (Breg) cells remain ill-defined. Here we
report an" auto"-regulatory feedback mechanism between plasmacytoid dendritic cells …

Many successful vaccines induce persistent antibody responses that can last a lifetime. The
mechanisms by which they do so remain unclear, but emerging evidence indicates that they …

Interferons (IFN) are subdivided into type I IFN (IFN-I, here synonymous with IFN-α/β), type II
(IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through …

Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet
promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the …

Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …

Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a
murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody …

Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents
and to restrict autoimmune responses against self antigens. Although factors participating in …

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that
generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to …