Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
Encapsulation, release, and cytotoxicity of doxorubicin loaded in liposomes, micelles, and metal-organic frameworks: a review
Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its
high efficacy and evident antitumoral activity on several cancer types. However, its effective …
high efficacy and evident antitumoral activity on several cancer types. However, its effective …
Localized blood–brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions–controlled focused ultrasound
Pharmacological treatment of gliomas and other brain-infiltrating tumors remains
challenging due to limited delivery of most therapeutics across the blood–brain barrier …
challenging due to limited delivery of most therapeutics across the blood–brain barrier …
[HTML][HTML] High intensity focused ultrasound in clinical tumor ablation
YF Zhou - World journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Recent advances in high intensity focused ultrasound (HIFU), which was developed in the
1940s as a viable thermal tissue ablation approach, have increased its popularity. In clinics …
1940s as a viable thermal tissue ablation approach, have increased its popularity. In clinics …
Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications
Ultrasound-triggered drug delivery is now becoming a mature technology with first patients
enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes …
enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes …
Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis
I De Cock, E Zagato, K Braeckmans, Y Luan… - Journal of controlled …, 2015 - Elsevier
Although promising results are achieved in ultrasound mediated drug delivery, its underlying
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …
Ultrasound mediated delivery of drugs and genes to solid tumors
V Frenkel - Advanced drug delivery reviews, 2008 - Elsevier
It has long been shown that therapeutic ultrasound can be used effectively to ablate solid
tumors, and a variety of cancers are presently being treated in the clinic using these types of …
tumors, and a variety of cancers are presently being treated in the clinic using these types of …
Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment
Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The blood–brain barrier
(BBB) provides a major obstacle to chemotherapy since therapeutic doses cannot be …
(BBB) provides a major obstacle to chemotherapy since therapeutic doses cannot be …
Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer
N Rapoport - Wiley Interdisciplinary Reviews: Nanomedicine …, 2012 - Wiley Online Library
This review focuses on phase‐shift perfluorocarbon nanoemulsions whose action depends
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …
Mechanism of intracellular delivery by acoustic cavitation
RK Schlicher, H Radhakrishna, TP Tolentino… - Ultrasound in medicine …, 2006 - Elsevier
Using conditions different from conventional medical imaging or laboratory cell lysis,
ultrasound has recently been shown to reversibly increase plasma membrane permeability …
ultrasound has recently been shown to reversibly increase plasma membrane permeability …