It has recently become possible to characterize a variety of different receptors by studying
the binding of appropriate drugs labelled with 3 H or 125 I. The goal of this review is to …

There are five subtypes of muscarinic acetylcholine receptors (M1 to M5) which control a
large number of physiological processes, such as the function of heart and smooth muscles …

Revised Manuscript Received April 29, 1993 abstract: We have probed the relative
contribution of polar and nonpolar interactions to antibody-antigen interaction by measuring …

Following a recent description of fluorescence resonance energy transfer between
enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and …

The salivary secretion from the cat submandibular salivary gland induced by
parasympathetic nerve stimulation is considered to be due to release of acetylcholine (ACh) …

Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated
from the orthosteric binding site for the endogenous neurotransmitter. Allosteric modulators …

[3H](+/-) Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to
characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from …

Ligand binding to G protein-coupled receptors is a complex process that involves sequential
receptor conformational changes, ligand translocation, and possibly ligand-induced receptor …

Radioligand binding has been used for many years to identify new binding sites,
characterize receptors, and identify novel ligands. Although various techniques have been …

Binding assays involving various antagonists, including N-[3H] methylscopolamine,[3H]
quinuclidinyl benzilate, AFDX-116, pirenzepine, and propylbenzilylcholine mustard …