determination and the implementation of preventive, diagnostic or therapeutic medical
strategies. However, the ESC Guidelines do not override in any way whatsoever the …

Venous thromboembolism (VTE) is a serious and often fatal medical condition with an
increasing incidence. The treatment of VTE is undergoing tremendous changes with the …

The aim of this updated statement is to provide comprehensive and timely evidence-based
recommendations on the prevention of stroke among individuals who have not previously …

Background and Purpose—This guideline provides an overview of the evidence on
established and emerging risk factors for stroke to provide evidence-based …

Anticoagulation with vitamin K antagonists (VKAs) has been shown to be effective in the
prevention and treatment of thrombotic complications in various clinical settings, including …

Background—Anticoagulation control with warfarin, as assessed by the international
normalized ratio (INR), is challenging. Time in the therapeutic range has been inversely …

Background & Aims Proton pump inhibitors (PPIs) might reduce the risk of serious warfarin-
related upper gastrointestinal bleeding, but the evidence of their efficacy for this indication is …

Anticoagulation for atrial fibrillation has become more complex due to the introduction of
new anticoagulant agents, the number and kinds of patients requiring therapy, and the …

This article discusses how we approach medical decision making in the treatment of the
various facets of the antiphospholipid syndrome (APS), including secondary prophylaxis in …

Purpose Evaluation of genomic tests is often challenging because of the lack of direct
evidence of clinical benefit compared with usual care and unclear evidence requirements …