Introduction Friedreich's ataxia is the most common inherited ataxia. Sources of data
Literature search using PubMed with keywords Friedreich's ataxia together with published …

Friedreich ataxia is the most common of the hereditary ataxias. It is due to homozygous/
compound heterozygous mutations in FXN. This gene encodes frataxin, a protein largely …

Friedreich ataxia (FRDA) is an autosomal-recessive disorder characterized by progressive
neurological and cardiac abnormalities. It predominantly affects individuals of European and …

The release of paused RNA polymerase II into productive elongation is highly regulated,
especially at genes that affect human development and disease. To exert control over this …

Background Friedreich's ataxia is a progressive degenerative disorder caused by deficiency
of the frataxin protein. Expanded GAA repeats within intron 1 of the frataxin (FXN) gene lead …

Objective We conducted a 6‐month, randomized, double‐blind, placebo‐controlled study to
assess safety, tolerability, and efficacy of deferiprone in Friedreich ataxia (FRDA). Methods …

Iron, copper and zinc are transition metals essential for life because they are required in a
multitude of biological processes. Organisms have evolved to acquire metals from nutrition …

Friedreich ataxia (FRDA), the most common inherited ataxia, is caused by transcriptional
silencing of the nuclear FXN gene, encoding the essential mitochondrial protein frataxin …

Friedreich ataxia (FRDA) is an autosomal recessive inherited multisystem disease,
characterized by marked differences in the vulnerability of neuronal systems. In general, the …

In eukaryotic genomes, heterochromatin is targeted by RNAi machinery and/or by pathways
requiring RNA elimination and transcription termination factors. However, a direct …