[HTML][HTML] Integrating across behaviors and timescales to understand the neural control of movement
The nervous system evolved to enable navigation throughout the environment in the pursuit
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa
Objective The development of novel treatments for anorexia nervosa (AN) requires a
detailed understanding of the biological underpinnings of specific, commonly occurring …
detailed understanding of the biological underpinnings of specific, commonly occurring …
Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning
H Vitet, J Bruyère, H Xu, C Séris, J Brocard, YS Abada… - Elife, 2023 - elifesciences.org
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
Layer 5 intratelencephalic neurons in the motor cortex stably encode skilled movement
The primary motor cortex (M1) and the dorsal striatum play a critical role in motor learning
and the retention of learned behaviors. Motor representations of corticostriatal ensembles …
and the retention of learned behaviors. Motor representations of corticostriatal ensembles …
Specific patterns of neural activity in the hippocampus after massed or distributed spatial training
Training with long inter-session intervals, termed distributed training, has long been known
to be superior to training with short intervals, termed massed training. In the present study …
to be superior to training with short intervals, termed massed training. In the present study …
Cell-Type Specific Connectivity of Whisker-Related Sensory and Motor Cortical Input to Dorsal Striatum
The anterior dorsolateral striatum (DLS) is heavily innervated by convergent excitatory
projections from the primary motor (M1) and sensory cortex (S1) and considered an …
projections from the primary motor (M1) and sensory cortex (S1) and considered an …
Competing neural representations of choice shape evidence accumulation in humans
Making adaptive choices in dynamic environments requires flexible decision policies.
Previously, we showed how shifts in outcome contingency change the evidence …
Previously, we showed how shifts in outcome contingency change the evidence …
Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity
The capacity of the brain to compensate for insults during development depends on the type
of cell loss, whereas the consequences of genetic mutations in the same neurons are …
of cell loss, whereas the consequences of genetic mutations in the same neurons are …
Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions
Understanding how the brain's macroscale dynamics are shaped by underlying microscale
mechanisms is a key problem in neuroscience. In animal models, we can now investigate …
mechanisms is a key problem in neuroscience. In animal models, we can now investigate …
Hippocampal motor memory network reorganization depends on familiarity, not time
DG Sullens, P Nguyen, K Gilley, MB Wiffler… - Learning & …, 2023 - learnmem.cshlp.org
There is debate as to whether a time-dependent transformation of the episodic-like memory
network is observed for nonepisodic tasks, including procedural motor memory. To …
network is observed for nonepisodic tasks, including procedural motor memory. To …