Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants

JN Paulson, BL Williams, C Hehnly, N Mishra… - Science translational …, 2020 - science.org
Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most
common cause of pediatric hydrocephalus worldwide, yet the microbial pathogens …

[HTML][HTML] The problem of microbial dark matter in neonatal sepsis

SA Sinnar, SJ Schiff - Emerging infectious diseases, 2020 - ncbi.nlm.nih.gov
Abstract Neonatal sepsis (NS) kills 750,000 infants every year. Effectively treating NS
requires timely diagnosis and antimicrobial therapy matched to the causative pathogens, but …

[HTML][HTML] Genomic insights into the biosynthesis and physiology of the cyanobacterial neurotoxin 3-N-methyl-2, 3-diaminopropanoic acid (BMAA)

MJQ Mantas, PB Nunn, GA Codd, D Barker - Phytochemistry, 2022 - Elsevier
Cyanobacteria are an ancient clade of photosynthetic prokaryotes, present in many habitats
throughout the world, including water resources. They can present health hazards to …

Human Paenibacillus Infections: A Systematic Review with Comparison of Adult and Infant Cases

D Smith, K Bastug, K Burgoine, JR Broach, C Hehnly… - medRxiv, 2023 - medrxiv.org
Neonatal infections due to Paenibacillus species have increasingly been reported over the
last few years. We performed a structured literature review of human Paenibacillus infections …

MinION whole-genome sequencing in resource-limited settings: Challenges and opportunities

FB Wasswa, K Kassaza, K Nielsen, J Bazira - Current Clinical …, 2022 - Springer
Abstract Purpose of Review The introduction of MinION whole-genome sequencing
technology greatly increased and simplified complete genome sequencing in various fields …

[HTML][HTML] Postoperative Paenibacillus thiaminolyticus wound infection, Switzerland

R Di Micco, M Schneider, R Nüesch - Emerging Infectious …, 2021 - ncbi.nlm.nih.gov
Paenibacillus thiaminolyticus is a nonvirulent organism found in human and ruminant
microbiota. However, P. thiaminolyticus can act as an opportunistic pathogen in humans. We …

Neonatal Paenibacilliosis: Paenibacillus thiaminolyticus as a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Uganda

JE Ericson, K Burgoine, E Kumbakumba, M Ochora… - medRxiv, 2022 - medrxiv.org
Paenibacillus thiaminolyticus may be an underdiagnosed cause of neonatal sepsis. We
prospectively enrolled a cohort of 800 neonates presenting with a clinical diagnosis of …

Type IV pili are a critical virulence factor in clinical isolates of Paenibacillus thiaminolyticus

C Hehnly, A Shi, P Ssentongo, L Zhang, A Isaacs… - MBio, 2022 - Am Soc Microbiol
Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly
prevalent in low-and middle-income countries. Hydrocephalus preceded by an infection, or …

Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study

SU Morton, C Hehnly, K Burgoine, P Ssentongo… - The Lancet …, 2023 - thelancet.com
Background Paenibacillus thiaminolyticus is a cause of postinfectious hydrocephalus
among Ugandan infants. To determine whether Paenibacillus spp is a pathogen in neonatal …

[PDF][PDF] Sepsis and Meningitis in Neonates and Young Children: Causes, Clinical Signs, and Treatment

CW Obiero - 2023 - core.ac.uk
UvA-DARE (Digital Academic Repository) Page 1 UvA-DARE is a service provided by the library
of the University of Amsterdam (https://dare.uva.nl) UvA-DARE (Digital Academic Repository) …