The intersection of immunology and nanotechnology has provided significant advancements
in biomedical research and clinical applications over the years. Immunology aims to …

Recent years have seen a marked increase in research on chimeric antigen receptor T
(CAR-T) cells, with specific relevance to the treatment of hematological malignancies. Here …

Chimeric antigen receptor (CAR) T-cell therapies have revolutionised the field of
haematological malignancies by achieving impressive remission rates in patients with highly …

While existing synthetic technologies for ex vivo T-cell activation face challenges like
suboptimal expansion rates and low effectiveness, artificial antigen-presenting cells …

In the past decade, nucleic acid therapies have seen a boon in development and clinical
translation largely due to advances in nanotechnology that have enabled their safe and …

Highlights•Delivery of mRNAs encoding cytokines to modulate anticancer
immunity.•Silencing the expression of regulatory genes to overcome immune …

Chimeric antigen receptor (CAR) T cell therapy has implemented impressive advances in
the treatment of B-cell lymphoma. However, the complex production process of CAR T cells …

Messenger RNA (mRNA) has emerged as an innovative therapeutic modality, offering
promising avenues for the prevention and treatment of a variety of diseases. The …

Adoptive cell therapy with chimeric antigen receptor (CAR) has revolutionized cancer
treatment in the past decade. Now several adoptive cell therapies are approved, and …

Messenger RNA (mRNA)-based immunotherapies and protein in situ production therapies
hold great promise for addressing theoretically all the diseases characterized by aberrant …