During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Collective cellular migration within the epithelial layer impacts upon development, wound
healing and cancer invasion, but remains poorly understood. Prevailing conceptual …

INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing …

Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …

Size control is fundamental in tissue development and homeostasis,. Although the role of
cell proliferation in these processes has been widely studied, the mechanisms that control …

Tissue morphogenesis, homoeostasis and repair require cells to constantly monitor their
three-dimensional microenvironment and adapt their behaviours in response to local …

Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-
sized cellular space. However, the significance of the physical properties of cells remains …

As an injury heals, an embryo develops or a carcinoma spreads, epithelial cells
systematically change their shape. In each of these processes cell shape is studied …

The leukocyte Fcγ receptor (FcγR)-mediated response is important for the efficacy of
therapeutic antibodies; however, little is known about the role of FcγRs in other cell types …

The orientation of cell division along the long axis of the interphase cell—the century-old
Hertwig's rule—has profound roles in tissue proliferation, morphogenesis, architecture and …