The unique two-photon excitable luminescence and dual-emission ratio output features
endow organic molecule-based ratiometric two-photon fluorescence (RTPF) probes as …

Background Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary
for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a …

The function of a T cell depends on its subtype and activation state. Here, we show that
imaging of the autofluorescence lifetime signals of quiescent and activated T cells can be …

New tools are needed to match cancer patients with effective treatments. Patient-derived
organoids offer a high-throughput platform to personalize treatments and discover novel …

Monitoring subcellular functional and structural changes associated with metabolism is
essential for understanding healthy tissue development and the progression of numerous …

Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic
potential, which has recently been linked to high rates of fatty acid oxidation (FAO). Here we …

Two-photon imaging of endogenous fluorescence can provide physiological and metabolic
information from intact tissues. However, simultaneous imaging of multiple intrinsic …

Abstract While NAD (P) H fluorescence lifetime imaging (FLIM) can detect changes in flux
through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD …

Background Cisplatin (CDDP) is a mainstay treatment for advanced head and neck
squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired …

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum.
Although abnormal GABAergic receptor activation has been described in MB, studies have …