NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Activation of nuclear factor-κB (NF-κB), a key mediator of inducible transcription in immunity,
requires binding of NF-κB essential modulator (NEMO) to ubiquitinated substrates. Here, we …

The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐
component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK …

Inhibitor of κB (IκB) kinase (IKK) phosphorylates IκB proteins, leading to their degradation
and the liberation of nuclear factor κB for gene transcription. Here we report the crystal …

BACKGROUND: Human hypomorphic nuclear factor-κB essential modulator (NEMO)
mutations cause diverse clinical and immunologic phenotypes, but understanding of their …

An important property of NEMO, the core element of the IKK complex involved in NF‐κB
activation, resides in its ability to specifically recognize poly‐ubiquitin chains. A small …

NF-κBs are a family of transcription factors that control a number of essential cellular
functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities …

The prosurvival transcription factor NF-κB specifically binds promoter DNA to activate target
gene expression. NF-κB is regulated through interactions with IκB inhibitor proteins. Active …

X-linked recessive ectodermal dysplasia with immunodeficiency is a rare primary
immunodeficiency caused by hypomorphic mutations of the IKBKG gene encoding the …