Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After
more than three decades of intensive research, understanding its spatiotemporal features is …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

BCR-ABL1-targeting tyrosine kinase inhibitors (TKIs) have revolutionized treatment of
Philadelphia chromosome-positive (Ph+) hematologic neoplasms. Nevertheless, acquired …

Highlights•CML is a hematopoietic stem cell disorder caused by a chromosomal
translocation.•TKIs have transformed CML treatment but do not eradicate LSC which …

Growing evidence suggests a major role for Src-homology-2-domain-containing
phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic …

Protein tyrosine phosphorylation is critical for proper function of cells and organisms.
Phosphorylation is regulated by the concerted but generically opposing activities of tyrosine …

Simple Summary The chromosomal alteration t (9; 22) generating the BCR-ABL1 fusion
protein represents the principal feature that distinguishes some types of leukemia. An …

Our previous studies have found that Growth factor receptor-bound protein 2–associated
binding protein 2 (Gab2)—a docking protein—governs the development of fatty liver …

Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor
prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A …

The scaffold/adaptor growth factor receptor bound 2 (GRB2)-associated binding protein 2
(GAB2) is frequently amplified and/or overexpressed in primary high-grade serous ovarian …