Dorsal root ganglia sensory neuronal cultures: a tool for drug discovery for peripheral neuropathies
Background: Peripheral neuropathies affect many people worldwide and are caused by or
associated with a wide range of conditions, both genetic and acquired. Current therapies are …
associated with a wide range of conditions, both genetic and acquired. Current therapies are …
Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?
KL Farmer, C Li, RT Dobrowsky - Pharmacological reviews, 2012 - ASPET
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is
associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of …
associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of …
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
G Landouré, AA Zdebik, TL Martinez, BG Burnett… - Nature …, 2010 - nature.com
Abstract Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant
neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two …
neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two …
The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy
SG Dorsey, IR Kleckner, D Barton… - JNCI: Journal of the …, 2019 - academic.oup.com
Although recent scientific advances have improved our understanding of basic biological
mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN), few …
mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN), few …
Spatial and transcriptomic analysis of perineural invasion in oral cancer
Abstract Purpose: Perineural invasion (PNI), a common occurrence in oral squamous cell
carcinomas, is associated with poor survival. Consequently, these tumors are treated …
carcinomas, is associated with poor survival. Consequently, these tumors are treated …
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling
Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around,
and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC) …
and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC) …
[HTML][HTML] Kynurenines link chronic inflammation to functional decline and physical frailty
Chronic inflammation is associated with physical frailty and functional decline in older
adults; however, the molecular mechanisms of this linkage are not understood. A mouse …
adults; however, the molecular mechanisms of this linkage are not understood. A mouse …
Melatonin limits paclitaxel‐induced mitochondrial dysfunction in vitro and protects against paclitaxel‐induced neuropathic pain in the rat
HF Galley, B McCormick, KL Wilson… - Journal of pineal …, 2017 - Wiley Online Library
Chemotherapy‐induced neuropathic pain is a debilitating and common side effect of cancer
treatment. Mitochondrial dysfunction associated with oxidative stress in peripheral nerves …
treatment. Mitochondrial dysfunction associated with oxidative stress in peripheral nerves …
[HTML][HTML] The effect of electrospun gelatin fibers alignment on schwann cell and axon behavior and organization in the perspective of artificial nerve design
S Gnavi, BE Fornasari, C Tonda-Turo… - International Journal of …, 2015 - mdpi.com
Electrospun fibrous substrates mimicking extracellular matrices can be prepared by
electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial …
electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial …
[HTML][HTML] VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro
Vascular endothelial growth factor (VEGF) A is generated as two isoform families by
alternative RNA splicing, represented by VEGF-A 165 a and VEGF-A 165 b. These isoforms …
alternative RNA splicing, represented by VEGF-A 165 a and VEGF-A 165 b. These isoforms …