Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Pain is an unpleasant sensory and emotional experience. Understanding the neural
mechanisms of acute and chronic pain and the brain changes affecting pain factors is …

Aim Despite an improved understanding of the molecular mechanisms of nociception,
existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as …

Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …

Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of
people on a daily basis. Sensory neurons known as nociceptors built specifically to detect …

Exposure to high-fat diet induces both, peripheral and central alterations in TLR4
expression. Moreover, functional TLR4 is required for the development of high-fat diet …

The importance of the periwound skin as the 'organ of healing'in the skin should not be
underestimated. This paper explores the numerous healing processes originating in the …

Generalized pustular psoriasis (GPP) is a rare, chronic skin disease, characterized by
widespread pustules and erythema, often accompanied with systemic signs and symptoms …

Ethnopharmacological relevance Schisandra chinensis, the dried and ripe fruit of the
magnolia family plant Schisandra chinensis (Turcz.) Baill, was commonly used in traditional …

Environmental disruption of the circadian rhythm is linked with increased pain due to
osteoarthritis (OA). We aimed to characterize the role of the clock gene in OA-induced pain …