Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

Physical activity, and specifically exercise, has been suggested as a potential treatment for
drug addiction. In this review, we discuss clinical and preclinical evidence for the efficacy of …

Cue-induced methamphetamine seeking progressively increases after withdrawal
(incubation of methamphetamine craving), but the underlying mechanisms are largely …

Theories of drug addiction that incorporate various concepts from the fields of learning and
memory have led to the idea that classical and operant conditioning principles underlie the …

The craving response to smoking-associated cues in humans or to intravenous nicotine-
associated cues in adult rats progressively increases or incubates after withdrawal. Here, we …

Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have
been identified as novel therapeutic targets based on extensive research supporting their …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Glutamatergic excitatory transmission is implicated in physiological and pathological
conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic …

Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This
study builds on efforts to identify neural markers of relapse risk by studying resting-state …

Cocaine self-administration decreases type 5 metabotropic glutamate receptor (mGluR5)
tissue concentrations in laboratory rats during early abstinence. These changes are thought …