Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

The primary hemostatic function of platelets has been recognized for more than a century,
but increasing experimental and clinical evidences suggest that platelets are also important …

Because metastasis is associated with the majority of cancer-related deaths, its prevention is
a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the …

Extensive experimental evidence indicates that platelets contribute to tumor cell proliferation
and metastasis through direct interactions and secreted bioactive proteins. Activated …

Until recently, the nucleic acid content of platelets was considered to be fully determined by
their progenitor megakaryocyte. However, it is now well understood that additional …

Platelets promote metastasis, however, their role in tumor growth remains controversial.
Here, we investigated the effect of platelet interactions with colorectal tumor cells. Platelets …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

The growing insights in the complex interactions between metastatic cancer-cells and
platelets have revealed that platelet tumor cell interactions in the blood stream are an …

The platelet P2Y12 receptor (P2Y12R) for adenosine 5′ diphosphate (ADP) plays a central
role in platelet function, hemostasis, and thrombosis. Patients with inherited P2Y12R defects …

Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …