The pyridazine heterocycle in molecular recognition and drug discovery
NA Meanwell - Medicinal Chemistry Research, 2023 - Springer
The pyridazine ring is endowed with unique physicochemical properties, characterized by
weak basicity, a high dipole moment that subtends π-π stacking interactions and robust …
weak basicity, a high dipole moment that subtends π-π stacking interactions and robust …
Recent advances in the chemistry of pyridazine—an important representative of six-membered nitrogen heterocycles
PG Sergeev, VG Nenajdenko - Russian Chemical Reviews, 2020 - iopscience.iop.org
The review is devoted to recent advances in the chemistry of pyridazine—a six-membered
heterocycle containing two nitrogen atoms in adjacent positions. The practical significance …
heterocycle containing two nitrogen atoms in adjacent positions. The practical significance …
Steroidal pyrimidines and dihydrotriazines as novel classes of anticancer agents against hormone-dependent breast cancer cells
AM Scherbakov, AV Komkov… - Frontiers in …, 2018 - frontiersin.org
Most breast and prostate tumors are hormone-dependent, making it possible to use
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …
New pyridazine-based binuclear nickel (II), copper (II) and zinc (II) complexes as prospective anticancer agents
UM Rafi, D Mahendiran, AK Haleel… - New Journal of …, 2016 - pubs.rsc.org
A new class of pyridazine-based binuclear nickel (II), copper (II) and zinc (II) complexes of
the type [M2 (L1–3) 2](NO3) 2 (1–9) with tridentate Schiff base ligands 3-chloro-6 …
the type [M2 (L1–3) 2](NO3) 2 (1–9) with tridentate Schiff base ligands 3-chloro-6 …
Visible-Light-Promoted [5 + 1] Annulation Initiated by Electron-Donor–Acceptor Complexes: Synthesis of Perfluoroalkyl-s-Triazines
R Wang, L Wang, Q Xu, BY Ren, F Liang - Organic letters, 2019 - ACS Publications
A visible-light-promoted electron-donor–acceptor (EDA) complex-initiated [5+ 1] annulation
between biguanides and perfluoroalkyl halides for the construction of perfluoroalkyl-s …
between biguanides and perfluoroalkyl halides for the construction of perfluoroalkyl-s …
Access to steroidal pyridazines via modified thiohydrazides
YA Volkova, YS Antonov, AV Komkov… - RSC …, 2016 - pubs.rsc.org
An approach to steroids annulated with pyridazines via cascade imination/electrocyclization
of chlorovinyl aldehydes with oxamic acid thiohydrazides is disclosed. A mechanistic …
of chlorovinyl aldehydes with oxamic acid thiohydrazides is disclosed. A mechanistic …
Novel steroidal 1, 3, 4-thiadiazines: Synthesis and biological evaluation in androgen receptor-positive prostate cancer 22Rv1 cells
AS Komendantova, AM Scherbakov, AV Komkov… - Bioorganic …, 2019 - Elsevier
A flexible approach to previously unknown spirofused and linked 1, 3, 4-thiadiazine
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …
Copper-catalysed dehydrogenative self-coupling/cyclization of 5-aminopyrazoles: synthesis and photophysical study of pyridazines
GK Rastogi, ML Deb, PK Baruah - Chemical Communications, 2023 - pubs.rsc.org
An interesting self-coupling/cyclization of 5-aminopyrazoles is revealed, which provides a
variety of pyridazine cores in reasonable yields. In this reaction, C (sp2)–C (sp2) and N–N …
variety of pyridazine cores in reasonable yields. In this reaction, C (sp2)–C (sp2) and N–N …
Iodine-promoted synthesis of pyrazoles from 1, 3-dicarbonyl compounds and oxamic acid thiohydrazides
AS Komendantova, KA Lyssenko, IV Zavarzin… - Organic Chemistry …, 2020 - pubs.rsc.org
A novel approach to the synthesis of 3, 4-dicarbonyl-substituted pyrazoles from a wide range
of 1, 3-dicarbonyl compounds and oxamic acid thiohydrazides was developed via iodine …
of 1, 3-dicarbonyl compounds and oxamic acid thiohydrazides was developed via iodine …
I 2-Promoted [4+ 2] cycloaddition of in situ generated azoalkenes with enaminones: facile and efficient synthesis of 1, 4-dihydropyridazines and pyridazines
J Feng, T He, Y Xie, Y Yu, JB Baell… - Organic & Biomolecular …, 2020 - pubs.rsc.org
A facile and efficient strategy for the synthesis of 1, 4-dihydropyridazines and pyridazines
through I2-promoted [4+ 2] cycloaddition of in situ generated azoalkenes with enaminones …
through I2-promoted [4+ 2] cycloaddition of in situ generated azoalkenes with enaminones …