Abstract Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes
during development and disease, among which cardiovascular disease, cancer, and …

Stromal cells are a subject of rapidly growing immunological interest based on their ability to
influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue …

Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …

Background We have previously shown that oncostatin M (OSM) levels are increased in
nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in …

The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule
regulating interactions between cells and their surrounding extracellular matrix (ECM). This …

Asthma is a chronic disease related to airway hyperresponsiveness and airway remodeling.
Airway remodeling is the important reason of refractory asthma and is associated with …

Oncostatin M (OSM) is a pleiotropic cytokine involved in a variety of inflammatory responses
such as wound healing, liver regeneration, and bone remodeling. As a member of the …

Background Airway hyperresponsiveness is a major feature of asthma attributed
predominantly to an extrinsic immune/inflammatory response increasing airway smooth …

The field of stromal immunology has risen to prominence in the last decade, fuelled by
accumulating evidence that nonhaematopoietic mesenchymal cells are not simply involved …

Mucosal epithelium maintains tissue homeostasis through many processes, including
epithelial barrier function, which separates the environment from the tissue. The barrier …