▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it
is clear that tumors express many neoantigens. A central question in cancer immunology is …

▪ Abstract The Tec family tyrosine kinases are now recognized as important mediators of
antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec …

Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI)
provides a reversible means of recruiting proteins to the plasma membrane, with the …

Abstract Naive Itk-deficient CD4+ T cells were unable to establish stable IL-4 production,
even when primed in Th2-inducing conditions. In contrast, IFNγ production was little …

Activation of Akt by multiple stimuli including B cell antigen receptor (BCR) engagement
requires phosphatidylinositol 3-kinase and regulates processes including cell survival …

Phospholipase C gamma (PLCγ) isoforms are critical for the generation of calcium signals in
haematopoietic systems in response to the stimulation of immune receptors. PLCγ is unique …

Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance
to therapies. Recent studies have reported that HCC may be derived not only from adult …

Abstract Thrombospondin-1 (TSP) is a transiently expressed matricellular protein known to
promote chemotaxis of leukocytes to inflammatory sites. However, TSP and its receptor …

The T cell, Ig domain, and mucin domain-1 (TIM-1) gene is associated with Th2 T cell
responses and human atopic diseases. The mechanism by which TIM-1 influences T cell …