SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as a …

Ewing sarcoma is a primary bone tumor initiated by EWSR1–ETS gene fusions. To identify
secondary genetic lesions that contribute to tumor progression, we performed whole …

Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase
II. Multiple subunits of the complex show specificity in relaying information from signals and …

Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate
chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its …

Faithful transmission of genetic material is crucial for all organisms since changes in genetic
information may result in genomic instability that causes developmental disorders and …

The ring-shaped cohesin complex topologically entraps chromosomes and regulates
chromosome segregation, transcription, and DNA repair. The cohesin core consists of the …

SMC1A encodes one of the proteins of the cohesin complex. SMC1A variants are known to
cause a phenotype resembling Cornelia de Lange syndrome (CdLS). Exome sequencing …

Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous
essential events in development, and serves as a stem cell niche signal in many contexts …

The end joining of distant DNA double-strand ends (DSEs) can produce potentially
deleterious rearrangements. We show that depletion of cohesion complex proteins …