1. Cough can (a) be an important defense mechanism to help clear excessive secretions
and foreign material from airways;(b) be an important factor in the spread of infection;(c) …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Background: A dry, persistent cough is a well-described class effect of the angiotensin-
converting enzyme (ACE) inhibitor medications. The mechanism of ACE inhibitor-induced …

Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase (s),
which occurred between 1958 and 1976, was followed by a classification system for …

Historically, the first described effect of an angiotensin converting enzyme (ACE) inhibitor
was an increased activity of bradykinin, one of the substrates of ACE. However, in the …

We present a two-part review of the English-language literature pertaining to drug therapy
for systemic high BP in patients with pulmonary diseases. Part I examines the literature …

Although data are incomplete, it appears that angiotensin-converting enzyme inhibitors
cause cough and angioedema through a cascade of effects that begins with the …

Despite many publications related to the identification of new angiotensin-I-converting
enzyme (ACE) inhibitors, especially peptides from natural products, the actual reason/s for …

OBJECTIVE: To compare the tolerability of angiotensin-converting enzyme (ACE) inhibitors
with that of angiotensin II (AII)-receptor blockers and the incidence of cough and …

Bradykinin has been implicated as a mediator of the acute pathophysiological and
inflammatory consequences of respiratory tract infections and in exacerbations of chronic …