Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review
Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …
Fluorinated chitosan to enhance transmucosal delivery of sonosensitizer-conjugated catalase for sonodynamic bladder cancer treatment post-intravesical instillation
G Li, S Wang, D Deng, Z Xiao, Z Dong, Z Wang, Q Lei… - Acs Nano, 2020 - ACS Publications
Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for
site-specific treatment of tumors with great depth penetration. The design of nano …
site-specific treatment of tumors with great depth penetration. The design of nano …
The actin cytoskeleton in cancer cell motility
Cancer cell metastasis is a multi-stage process involving invasion into surrounding tissue,
intravasation, transit in the blood or lymph, extravasation, and growth at a new site. Many of …
intravasation, transit in the blood or lymph, extravasation, and growth at a new site. Many of …
Functional diversity of protein phosphatase-1, a cellular economizer and reset button
H Ceulemans, M Bollen - Physiological reviews, 2004 - journals.physiology.org
Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …
ILK, PINCH and parvin: the tIPP of integrin signalling
KR Legate, E Montañez, O Kudlacek… - Nature reviews Molecular …, 2006 - nature.com
The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …
Mechanisms of vascular smooth muscle cell migration
WT Gerthoffer - Circulation research, 2007 - Am Heart Assoc
Smooth muscle cell migration occurs during vascular development, in response to vascular
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …
Integrin-linked kinase: a cancer therapeutic target unique among its ILK
G Hannigan, AA Troussard, S Dedhar - Nature Reviews Cancer, 2005 - nature.com
Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …
Myosin phosphatase: structure, regulation and function
M Ito, T Nakano, F Erdődi, DJ Hartshorne - Molecular and cellular …, 2004 - Springer
Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …
muscle contraction. The level of myosin II phosphorylation is determined by activities of …
Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
One of the hallmarks of cancers is the silencing of tumour suppressor genes and pathways.
The Hippo tumour suppressor pathway is inactivated in many types of cancers, leading to …
The Hippo tumour suppressor pathway is inactivated in many types of cancers, leading to …