The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for
site-specific treatment of tumors with great depth penetration. The design of nano …

Cancer cell metastasis is a multi-stage process involving invasion into surrounding tissue,
intravasation, transit in the blood or lymph, extravasation, and growth at a new site. Many of …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …

Smooth muscle cell migration occurs during vascular development, in response to vascular
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …

Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …

Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …

One of the hallmarks of cancers is the silencing of tumour suppressor genes and pathways.
The Hippo tumour suppressor pathway is inactivated in many types of cancers, leading to …