Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic …

Background: Epithelial barrier function is impaired in Crohn's disease. Aim: To define the
underlying cellular mechanisms with special attention to tight junctions. Methods: Biopsy …

Background & Aims: Ulcerative colitis (UC) is characterized by a Th2 immune response with
inflammation and epithelial barrier dysfunction. So far, Th2 cytokines have not been shown …

It is well known that inflammatory conditions of the intestinal mucosa result in compromised
barrier function. Inflammation is characterized by an influx into the mucosa of immune cells …

Background & Aims: Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown.
Functional and structural characterization of epithelial barrier and transport properties in …

The mechanisms by which commensal bacteria suppress inflammatory signalling in the gut
are still unclear. Here, we present a cellular mechanism whereby the polarity of intestinal …

Inflammatory bowel disease (IBD) consisting of ulcerative colitis (UC) and Crohn's (CD)
typically displays a waxing and waning course punctuated by disease flares that are …

Increased epithelial permeability is observed in inflammatory states. However, the
mechanism by which inflammatory mediators such as IFN‐γ increase epithelial permeability …

Cytokines are supposed to be mediators in diarrhoeal diseases. The aim of this study is to
characterize the effect of tumor necrosis factor-alpha (TNFα) on epithelial barrier function in …