Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

P Dhyani, C Quispe, E Sharma, A Bahukhandi… - Cancer cell …, 2022 - Springer
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application

AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Alkaloids for cancer prevention and therapy: Current progress and future perspectives

A Mondal, A Gandhi, C Fimognari, AG Atanasov… - European journal of …, 2019 - Elsevier
Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

[HTML][HTML] Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

AQ Khan, K Rashid, AA AlAmodi, MV Agha… - Biomedicine & …, 2021 - Elsevier
Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

[HTML][HTML] Anticancer drugs in the aquatic ecosystem: Environmental occurrence, ecotoxicological effect and risk assessment

D Li, H Chen, H Liu, D Schlenk, J Mu, S Lacorte… - Environment …, 2021 - Elsevier
Anticancer drugs are a group of therapeutic agents used to enhance cell death in targeted
cell types of neoplasia. Because of frequent use and eventual discharge, they have been …

Plants as a source of anticancer agents: From bench to bedside

WH Talib, S Daoud, AI Mahmod, RA Hamed, D Awajan… - Molecules, 2022 - mdpi.com
Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated …

V Shrihastini, P Muthuramalingam, S Adarshan… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

Alkaloid from Geissospermum sericeum Benth. & Hook.f. ex Miers (Apocynaceae) Induce Apoptosis by Caspase Pathway in Human Gastric Cancer Cells

ML Carmo Bastos, JV Silva-Silva, J Neves Cruz… - Pharmaceuticals, 2023 - mdpi.com
Gastric cancer is among the major causes of death from neoplasia leading causes of death
worldwide, with high incidence rates and problems related to its treatment. Here, we outline …

Recent advances in improved anticancer efficacies of camptothecin nano-formulations: A systematic review

M Ghanbari-Movahed, T Kaceli, A Mondal, MH Farzaei… - Biomedicines, 2021 - mdpi.com
Camptothecin (CPT), a natural plant alkaloid, has indicated potent antitumor activities via
targeting intracellular topoisomerase I. The promise that CPT holds in therapies is restricted …