Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

Posttraumatic stress disorder is a serious and often disabling syndrome that develops in
response to a traumatic event. Many individuals who initially develop the disorder go on to …

The purpose of our study was to better understand the relationship between mitochondrial
structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The mitochondrial electron transport chain (ETC) plays a central role in energy generation in
the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and …

Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-
related diseases and neurodegeneration. In this paper, we review evidence relevant to the …

The objective of this study was to determine the protective effects of the mitochondria-
targeted molecules MitoQ and SS31 in striatal neurons that stably express mutant huntingtin …

Asthma is a complex, inflammatory disorder characterized by airflow obstruction of variable
degrees, bronchial hyper-responsiveness, and airway inflammation. Asthma is caused by …

Oxidative stress and mitochondrial dysfunction are involved in the progression and
pathogenesis of multiple sclerosis (MS). MitoQ is a mitochondria-targeted antioxidant that …

Background: Pesticide exposure is associated with many long-term health outcomes; the
potential underlying mechanisms are not well established for most associations. Epigenetic …